Therapeutic approaches for corneal neovascularization
نویسندگان
چکیده
منابع مشابه
Therapeutic approaches for corneal neovascularization
Angiogenesis refers to new blood vessels that originate from pre-existing vascular structures. Corneal neovascularization which can lead to compromised visual acuity occurs in a wide variety of corneal pathologies. A large subset of measures has been advocated to prevent and/or treat corneal neovascularization with varying degrees of success. These approaches include topical corticosteroid admi...
متن کاملTopical bevacizumab therapy for corneal neovascularization.
Angiogenesis has been defined as the formation of new blood vessels from preexisting vascular structures. Corneal neovascularization (NV) occurs when the balance between angiogenic and antiangiogenic factors shifts toward angiogenic factors. Vascular endothelial growth factor (VEGF) has been found to be a significant angiogenic factor in corneal NV in human and animal models. Therapy specifical...
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Purpose: feasibility of local application of bevacizumab for inhibition and treatment of corneal angiogenesis. Materials and Methods: 20 pigmented rabbits with average weight 3.7±0.4 kg were numbered and two groups were made, Group A: the rabbits of this group were subjected to corneal sutures application to induce corneal vascularization. Group B: rabbits of this group were subjected to cornea...
متن کاملCorneal Neovascularization: A Translational Perspective
Corneal neovascularization (CNV) results from the growth of new vessels from the limbal vasculature into the normally avascular cornea. As the second cause of severe visual impairment worldwide, it represents a major clinical problem. This occurs because CNV often leads to corneal opacification, thus reducing visual acuity. CNV is a well characterized and complex process, which includes differe...
متن کاملCorneal neovascularization and biological therapy
Corneal avascularity is necessary for the preservation of optimal vision. The cornea maintains a dynamic balance between pro- and antiangiogenic factors that allows it to remain avascular under normal homeostatic conditions. Corneal neovascularization (NV) is a condition that can develop in response to inflammation, hypoxia, trauma, or limbal stem cell deficiency and it is a significant cause o...
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ژورنال
عنوان ژورنال: Eye and Vision
سال: 2017
ISSN: 2326-0254
DOI: 10.1186/s40662-017-0094-6